Reacción #64141

Ecuación de reacción

1-(4-bromobenzoyl)-4-(2-hydroxyphenyl)-4-hydroxypiperidine

potassium carbonate

ethylα-bromoisobutyrate

water

→

ethyl 3-{1-(4-bromobenzoyl)-4-hydroxypiperidin-4-yl}α,α-dimethylphenoxyacetate

Rendimiento 86.4%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter completion of the reaction
2. 2
   TemperaturaThe reaction mixture was cooled
3. 3
   Extracciónfollowed by extraction with chloroform
4. 4
   SecadoSubsequently, the extract was dried over anhydrous sodium sulfate
5. 5
   workup.DISTILLATIONChloroform and the remained ethyl α-bromoisobutyrate was distilled off under reduced pressure

Procedimiento

801 mg of {1-(4-bromobenzoyl)-4-(2-hydroxyphenyl)-4-hydroxypiperidine was stirred for 9 hours at the ambient temperature of 100° C. in the presence of 1.20 g (8.68 mmol) of potassium carbonate in 4.00 g (20.5 ml) of ethylα-bromoisobutyrate. After completion of the reaction, The reaction mixture was cooled, and water was added thereto, followed by extraction with chloroform. Subsequently, the extract was dried over anhydrous sodium sulfate. Chloroform and the remained ethyl α-bromoisobutyrate was distilled off under reduced pressure to obtain 902 mg (86.4%) of ethyl 3-{1-(4-bromobenzoyl)-4-hydroxypiperidin-4-yl}α,α-dimethylphenoxyacetate.

Fuente