Reacción #6414

Ecuación de reacción

p-hydroxybenzoic acid

(-)-2-methylbutanol

sulfuric acid

→

ester

Rendimiento 83.0%

2-methylbutyl 4-hydroxybenzoate

Rendimiento 83.0%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowhile removing the generated water out from the reaction system
2. 2
   LavadoSubsequently, the reaction solution was washed with water
3. 3
   Otroto remove sulfuric acid out
4. 4
   OtroThe reaction solution was then dried
5. 5
   Concentraciónconcentrated
6. 6
   Otrothe concentrate was purified by column chromatography

Procedimiento

4.0 g of p-hydroxybenzoic acid and 12.5 g of (-)-2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid, while removing the generated water out from the reaction system. Subsequently, the reaction solution was washed with water to remove sulfuric acid out. The reaction solution was then dried and concentrated, and the concentrate was purified by column chromatography, to obtain 5.0 g of the objective ester compound (liquid state at room temperature, [α]D23 =4.9° (CHCl3)). (Yield: 83%)

Fuente