Reacción #641203

Ecuación de reacción

DL-α-lipoic acid

zinc

hydrochloric acid

→

6,8-dimercaptooctanoic acid zinc

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrounreacted zinc was removed by filtration
2. 2
   Concentraciónthe filtrate was concentrated under reduced pressure
3. 3
   workup.ADDITIONAddition of 150 ml of water
4. 4
   Otroto the oily residue, collection of thus precipitated white crystals
5. 5
   Filtraciónby filtration
6. 6
   Lavadowashing with water

Procedimiento

6.2 g of DL-α-lipoic acid was dissolved in 70 ml of methanol, and to this were added 3.5 g of zinc powder and 15 ml of 2 N hydrochloric acid and stirred for one hour at 50° C. When the solution turned colorless, unreacted zinc was removed by filtration, and the filtrate was concentrated under reduced pressure. Addition of 150 ml of water to the oily residue, collection of thus precipitated white crystals by filtration and washing with water gave the free acid form of 6,8-dimercaptooctanoic acid zinc chelate compound.

Fuente