Reacción #641157

Ecuación de reacción

hydrogen

(3S,8aR)-3-(2,4,6-trifluorophenyl)-2,3,6,8a-tetrahydro-1H-indolizin-5-one

→

title compound

Rendimiento 99.6%

(3S,8aR)-3-(2,4,6-trifluorophenyl)hexahydroindolizin-5-one

Rendimiento 99.6%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe reaction solution was filtered through celite
2. 2
   Concentraciónthe filtrate was concentrated under reduced pressure

Procedimiento

Platinum oxide (25 mg) was added to a solution of (3S,8aR)-3-(2,4,6-trifluorophenyl)-2,3,6,8a-tetrahydro-1H-indolizin-5-one (548 mg) in methanol (5 mL), and the reaction solution was stirred in a hydrogen atmosphere at 1 atm at room temperature for one hour. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 550 mg of the title compound. The property value of the compound is as follows.

Fuente