Reacción #640575

Ecuación de reacción

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

ammonium chloride

water

→

3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

Rendimiento 99.3%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato reflux for 1.5 hours
2. 2
   Filtraciónthe reaction mixture was filtered with suction
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   LavadoThe organic layer was washed with a saturated brine
5. 5
   Secadodried over anhydrous sodium sulfate

Procedimiento

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.59 g, 5.10 mmol), iron powder (1.42 g, 25.4 mmol), ammonium chloride (0.14 g, 2.62 mmol) were suspended in ethanol (30 ml) and water (15 ml) and heated to reflux for 1.5 hours. After cooling to room temperature, the reaction mixture was filtered with suction and extracted with ethyl acetate. The organic layer was washed with a saturated brine and then dried over anhydrous sodium sulfate, and 3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.43 g) was obtained by evaporating the solvent under reduced pressure.

Fuente