Reacción #640572

Ecuación de reacción

3-(2-Nitrobenzyl)-[1,3]-oxazinan-2-one

ammonium chloride

water

→

3-(2-aminobenzyl)-[1,3]-oxazinan-2-one

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato reflux for one hour
2. 2
   Filtraciónthe reaction mixture was filtered with suction
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   LavadoThe organic layer was washed with a saturated brine
5. 5
   Secadodried over anhydrous sodium sulfate

Procedimiento

3-(2-Nitrobenzyl)-[1,3]-oxazinan-2-one (0.24 g, 1.02 mmol), iron powder (0.28 g, 5.02 mmol), ammonium chloride (0.03 g, 0.56 mmol) were suspended in ethanol (10 ml) and water (5 ml) and heated to reflux for one hour. After cooling to room temperature, the reaction mixture was filtered with suction and extracted with ethyl acetate. The organic layer was washed with a saturated brine and then dried over anhydrous sodium sulfate, and 3-(2-aminobenzyl)-[1,3]-oxazinan-2-one was obtained by evaporating the solvent under reduced pressure (0.20 g).

Fuente