Reacción #640541

Ecuación de reacción

6-aminonicotinic acid

ethanol

→

white solid

Ethyl 6-Aminonicotinate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas bubbled in dry hydrochloric acid at 0° C.
2. 2
   Temperaturathe solution was refluxed until all the solids
3. 3
   workup.DISSOLUTIONdissolved
4. 4
   OtroThe solvents were removed under reduced pressure
5. 5
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
6. 6
   Lavadowashed with saturated sodium bicarbonate, brine
7. 7
   Concentraciónconcentrated

Procedimiento

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

Fuente