Reacción #640539

Ecuación de reacción

2,6-Dimethylaniline

ethyl bromoacetate

N-(2,6-Dimethylphenyl)glycine hydrobromide salt

→

N-(2,6 Dimethylphenyl)glycine

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA precipitated
2. 2
   Otroformed which
3. 3
   Otrowas collected
4. 4
   Otrotriturated with dichloromethane (25 mL)

Procedimiento

2,6-Dimethylaniline (6.1 g, 50.4 mmol), and ethyl bromoacetate (8.4 g, 50.4 mmol) were refluxed neat for 10 min. The reaction mixture was cooled to room temperature and poured into dichloromethane (75 mL). A precipitated formed which was collected and triturated with dichloromethane (25 mL). N-(2,6-Dimethylphenyl)glycine hydrobromide salt (1.21 g, 4.6 mmol, 9.0%) was collected as a white crystalline solid. 1H NMR (CD3OD) d 2.48 (s, 6H), 4.29 (s, 2H), 7.00-7.10 (m, 3H).

Fuente