Reacción #640531

Ecuación de reacción

4-[1-(4-chloro-3-nitrophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

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title compound

4-[1-(3-Amino-4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

Disolventes

ethanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónFiltration and evaporation at reduced pressure
2. 2
   Otrogives the crude product
3. 3
   OtroPurification
4. 4
   Extracciónby extraction with ethyl acetate and chromatography on silicagel

Procedimiento

To a stirred solution of 4-[1-(4-chloro-3-nitrophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.07 g, 0.175 mmol) in ethanol (6 ml) and water (1 ml) is added two drops of concentrated hydrochloric acid and iron powder (0.1 g, 17.5 mmol). The reaction mixture is heated at 80° C. for 8 hours. Filtration and evaporation at reduced pressure gives the crude product. Purification by extraction with ethyl acetate and chromatography on silicagel yields the title compound as colorless solid, m.p. 228-230° C.

Fuente