Reacción #640518

Ecuación de reacción

4-[1-(4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

potassium carbonate

dimethylsulfate

→

title compound

Methyl-{4-[1-(4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-yl}-amine

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónFiltration of the solids, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel

Procedimiento

A suspension of 4-[1-(4-chlorophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.10 g, 0.282 mmol, prepared according to Example 1), potassium carbonate (0.233 g, 1.69 mmol) and dimethylsulfate (0.142 g, 1.12 mmol) in acetone (5 ml) is stirred at room temperature for 16 hours. Filtration of the solids, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel using hexane-ethyl acetate as eluent gives the title compound as a colorless solid, m.p. 210-214° C.

Fuente