Reacción #640517

Ecuación de reacción

4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

sodium bicarbonate

hydroxylamine hydrochloride

→

title compound

4-[1-(4-Bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine oxime

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturais refluxed for 20 hours
2. 2
   OtroPartitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase
3. 3
   Otroby drying
4. 4
   Otroevaporation of the solvent
5. 5
   Otrogives the crude product
6. 6
   OtroPurification by chromatography on silicagel

Procedimiento

A mixture of 4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.083 g, 0.21 mmol, prepared according to Example 1), sodium bicarbonate (0.021 g, 0.25 mmol) and hydroxylamine hydrochloride (0.014 g, 0.21 mmol) in ethanol (5 ml) is refluxed for 20 hours. Partitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase followed by drying and evaporation of the solvent gives the crude product. Purification by chromatography on silicagel yields the title compound as an E/Z-mixture, m.p. 198-201° C.

Fuente