Reacción #640516

Ecuación de reacción

Phenacylbromid

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

→

title compound

4-(1-Phenacyl-1H-benzimidazol-2-yl)-furazan-3-ylamine

Disolventes

DMF

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat room temperature
2. 2
   Lavadothe organic phase is washed repeatedly with brine
3. 3
   OtroDrying of the solvent
4. 4
   Filtraciónfiltering
5. 5
   Otroevaporation of the solvent under reduced pressure

Procedimiento

Phenacylbromid (0.1 g, 0.49 mmol) is added to an efficiently stirred suspension of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.1 g, 0.4 mmol) [A. V. Sergievskii, O. A. Krasnoshek, S. F. Mel'nikova, I. V. Tselinskii, Russian Journal of Organic Chemistry, 2002, 38, 915-917] and potassium carbonate (0.172 g, 1.24 mmol) in dry DMF (5 ml) at room temperature. After 4 hours the reaction mixture is diluted with ethyl acetate and the organic phase is washed repeatedly with brine. Drying of the solvent, filtering and evaporation of the solvent under reduced pressure gives the title compound in crude form. The title compound is obtained in pure form by chromatography over silicagel, m.p. 202-204° C.

Fuente