Reacción #63987

Ecuación de reacción

1-acetyl-1-(3,4-dichlorophenyl)cyclobutane

hydroxylamine hydrochloride

sodium acetate trihydrate

→

1-acetyl-1-(3,4-dichlorophenyl)cyclobutane oxime

Disolventes

—

industrial methylated spirit

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroprepared
2. 2
   Temperaturawas heated
3. 3
   Temperaturaunder reflux for twenty hours
4. 4
   OtroThe cooled reaction mixture
5. 5
   Otrothe oil which separated
6. 6
   Temperaturawas cooled
7. 7
   Otroto give a solid which
8. 8
   Otrowas recrystallised from industrial methylated spirit

Procedimiento

A mixture of 1-acetyl-1-(3,4-dichlorophenyl)cyclobutane (4.86 g) prepared as described in Example 1, hydroxylamine hydrochloride (1.6 g), sodium acetate trihydrate (3.3 g), industrial methylated spirit (15 ml) and water (2 ml) was heated under reflux for twenty hours. The cooled reaction mixture was poured into water and the oil which separated was cooled to give a solid which was recrystallised from industrial methylated spirit to give 1-acetyl-1-(3,4-dichlorophenyl)cyclobutane oxime (m.p. 120°-121° C.).

Fuente