Reacción #63979

Ecuación de reacción

hydrochloric acid

1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile

propyl magnesium bromide

ether

propyl bromide

magnesium

ether

ether

→

1-butyryl-1-(3,4-dichlorophenyl)cyclobutane

Disolventes

toluene

Water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture heated
2. 2
   Temperaturaunder reflux for one hour
3. 3
   Temperaturathe mixture heated
4. 4
   Temperaturaunder reflux for one hour
5. 5
   ExtracciónThe reaction mixture was extracted with ether
6. 6
   Lavadoafter washing
7. 7
   Otrodrying the extract

Procedimiento

A solution of 1-(3,4-dichlorophenyl)-1-cyclobutanecarbonitrile prepared as described in Example 1 (35.2 g) in ether (100 ml) was added to a solution of propyl magnesium bromide prepared by the reaction of propyl bromide (32 g) with magnesium turnings (6.36 g) in ether (100 ml). The ether was replaced by dry toluene and the mixture heated under reflux for one hour. Water (200 ml) and then concentrated hydrochloric acid (120 ml) were added and the mixture heated under reflux for one hour. The reaction mixture was extracted with ether and after washing and drying the extract yielded a residue from which 1-butyryl-1-(3,4-dichlorophenyl)cyclobutane (b.p. 120°-128° C. at 0.25 mm) was distilled.

Fuente