Reacción #63780

Ecuación de reacción

N-propargyl-2,4-dimethyl-5-(trifluoromethanesulfonamido)benzenesulfonamide

triethylamine

acetyl chloride

tetrahydrofuran

→

N-acetyl-N-propargyl-2,4-dimethyl-5-(N-acetyl-N-trifluormethanesulfonylamino)benzenesulfonamide

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated
2. 2
   Extracciónextracted with chloroform
3. 3
   ConcentraciónThe extract was concentrated
4. 4
   Otroto give an oily substance, which
5. 5
   Otrowas purified by silica gel chromatography

Procedimiento

To a solution of N-propargyl-2,4-dimethyl-5-(trifluoromethanesulfonamido)benzenesulfonamide (1.5 g) and triethylamine (1.2 g) in tetrahydrofuran (20 ml), acetyl chloride (1.0 g) was added, and the resultant mixture was allowed to stand at room temperature overnight. The reaction mixture was concentrated, admixed with 5% hydrochloric acid and extracted with chloroform. The extract was concentrated to give an oily substance, which was purified by silica gel chromatography to give 1.4 g of N-acetyl-N-propargyl-2,4-dimethyl-5-(N-acetyl-N-trifluormethanesulfonylamino)benzenesulfonamide (Compound No. 75). nD20 1.5209.

Fuente