Reacción #63670

Ecuación de reacción

4-fluoroacetanilide

2,6-difluoroacetanilide

acetanilide

2,4-difluoroacetanilide

fluoroxytrifluoromethane

→

2-fluoroacetanilide

Rendimiento 37.0%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas bubbled into the solution at a rate of 46 parts per hour

Procedimiento

A solution of 67.5 parts of acetanilide in 22,200 parts of chloroform was cooled to 0° C. and maintained at that temperature for 2.5 hours while fluoroxytrifluoromethane was bubbled into the solution at a rate of 46 parts per hour. Analysis of the reaction product by gas chromatographic technique indicated a 91 percent conversion with a yield of 37% 2-fluoroacetanilide, 16% 4-fluoroacetanilide, 10% 2,4-difluoroacetanilide, 3% 2,6-difluoroacetanilide and about 25% higher molecular weight material.

Fuente