Reacción #63574

Ecuación de reacción

water

2-chloroethanol

sulfuric acid

4-fluoro-α-(4-fluorophenyl)benzenemethanol

→

1,1'-[(2-chloroethoxy)methylene]bis[4-fluorobenzene]

Disolventes

benzene

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated on a water-bath
2. 2
   workup.ADDITIONAfter the addition
3. 3
   Temperaturarefluxed for 4 hours
4. 4
   TemperaturaAfter cooling the reaction mixture
5. 5
   OtroThe benzene layer was separated
6. 6
   Secadodried over calcium chloride
7. 7
   Otroevaporated
8. 8
   workup.DISTILLATIONThe residue was distilled in vacuo

Procedimiento

A mixture of 20 parts of 2-chloroethanol, 3 parts of sulfuric acid and 16 parts of benzene was heated on a water-bath. Then there were added dropwise 35 parts of 4-fluoro-α-(4-fluorophenyl)benzenemethanol dissolved in 32 parts of benzene. After the addition was complete, the whole was stirred and refluxed for 4 hours. After cooling the reaction mixture was poured into water. The benzene layer was separated, dried over calcium chloride and evaporated. The residue was distilled in vacuo, yielding 35 parts of 1,1'-[(2-chloroethoxy)methylene]bis[4-fluorobenzene]; bp. 164°-166° C. at 1.5 mm. pressure; nD20 : 1.5462; d2020 : 1.2290 (intermediate 1).

Fuente