Reacción #63461

Ecuación de reacción

6-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one

triethylamine

3,4-dimethoxybenzoylchloride

→

6-(3,4-Dihydro-4-(3,4-dimethoxyphenylcarbonyl)-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture heated
2. 2
   Temperaturaat reflux for four hours
3. 3
   LavadoThe solution was washed with sodium bicarbonate solution
4. 4
   Otroevaporated to dryness
5. 5
   OtroThe residue was chromatographed on silica gel eluting with 1:1 ethyl acetate
6. 6
   OtroThe title compound was collected as white needles, mp 207°-208° C.

Procedimiento

6-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one was dissolved in methylene chloride and 1.1 equivalent of triethylamine. 1.1 equivalent of 3,4-dimethoxybenzoylchloride was added and the mixture heated at reflux for four hours. The solution was washed with sodium bicarbonate solution and then evaporated to dryness. The residue was chromatographed on silica gel eluting with 1:1 ethyl acetate:ethyl ether. The title compound was collected as white needles, mp 207°-208° C.

Fuente