Reacción #63451

Ecuación de reacción

cyanogen bromide

6,7-dihydro-5H-dibenz[c,e]azepine

→

5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile

Disolventes

chloroform

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtracióna small amount of the hydrobromide salt of the still unreacted azepine is filtered off
2. 2
   LavadoThe filtrate is washed three times with water
3. 3
   Secadodried over anhydrous sodium sulphate
4. 4
   Otroevaporated

Procedimiento

A solution of 1.91 g of cyanogen bromide in 20 ml of chloroform is added dropwise at 5°-10° C. within 25 minutes to a solution, cooled to 5° C., of 7 g of 6,7-dihydro-5H-dibenz[c,e]azepine in 50 ml of chloroform. The reaction mixture is stirred for a further 1 hour and then a small amount of the hydrobromide salt of the still unreacted azepine is filtered off. The filtrate is washed three times with water, dried over anhydrous sodium sulphate and evaporated. There is obtained solid 5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile, m.p. 123°-126° C.

Fuente