Reacción #63449

Ecuación de reacción

5,7-dihydro-6H-dibenz[c,e]azepine-6-carboxamide

triethyloxonium tetrafluoroborate

sodium carbonate

→

ethyl 5,7-dihydro-6H-dibenz[c,e]azepine-6-caboximidate

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe whole is extracted with methylene chloride
2. 2
   LavadoThe combined extracts are washed with 10% sodium carbonate solution
3. 3
   Secadodried over anhydrous sodium sulphate
4. 4
   Otroevaporated under reduced pressure

Procedimiento

1.19 g of 5,7-dihydro-6H-dibenz[c,e]azepine-6-carboxamide are dissolved in 10 ml of methylene chloride, and the solution is treated with 1.14 g of triethyloxonium tetrafluoroborate and stirred at room temperature for 20 hours. The mixture is then poured on to 10% sodium carbonate solution/ice and the whole is extracted with methylene chloride. The combined extracts are washed with 10% sodium carbonate solution, dried over anhydrous sodium sulphate and evaporated under reduced pressure. In this manner there is obtained crude ethyl 5,7-dihydro-6H-dibenz[c,e]azepine-6-caboximidate which is purified by a filtration on silica gel [eluent: n-hexane/ethyl acetate (1:1)]; m.p. 74°-76° C. (crystallized from n-hexane).

Fuente