Reacción #63424

Ecuación de reacción

cyano-phenol

diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate

potassium carbonate

→

desired compound

Rendimiento 86.0%

diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate

Rendimiento 86.0%

Disolventes

dimethyl sulfoxide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONare added
2. 2
   FiltraciónThe reaction mixture is filtered
3. 3
   Otrothe filtrate is evaporated

Procedimiento

11.9 g of cyano-phenol and 32.6 g of diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate are dissolved in 150 ml of dimethyl sulfoxide, whereupon 13.8 g of potassium carbonate are added and the reaction mixture is stirred at 60° C. for 6 hours. The reaction mixture is filtered and the filtrate is evaporated. Thus 36 g of the desired compound are obtained, yield 86%.

Fuente