Reacción #6341

Ecuación de reacción

1,3-dibenzyloxypropan-2-ol

paraformaldehyde

Triethyl phosphite

→

title compound

Diethyl [2-benzyloxy-1-(benzyloxymethyl)ethoxy]methylphoshonate

Disolventes

dichloromethane

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroDry HCl gas was bubbled through an ice-
2. 2
   SecadoThe resulting solution was dried (MgSO4)
3. 3
   Otroevaporated to dryness
4. 4
   Otroto leave an oil
5. 5
   OtroThe liquid obtained
6. 6
   Lavadowashed with sodium bicarbonate solution
7. 7
   LavadoThe organic phase was washed with brine
8. 8
   Secadodried (MgSO4)
9. 9
   Otroevaporated
10. 10
    Otroto give a mobile oil, which

Procedimiento

Dry HCl gas was bubbled through an ice-cooled solution of 1,3-dibenzyloxypropan-2-ol (25 g, 0.092 mol) and paraformaldehyde (2.75 g, 0.092 mol) in dry dichloromethane (100 ml) for 1 hour. The resulting solution was dried (MgSO4) and evaporated to dryness to leave an oil. Triethyl phosphite (15.7 ml, 0.092 mol) was added and the resulting mixture stirred and heated at 140° C. for 16 hours. The liquid obtained was dissolved in ethyl acetate and washed with sodium bicarbonate solution. The organic phase was washed with brine, dried (MgSO4) and evaporated to give a mobile oil, which was chromotographed in silica (hexane/ethyl acetate 50:50 as eluant) to give the title compound as a colourless, mobile oil (19.7 g, 51). IR: νmax (film) 3055, 3020, 2900, 2860, 1490, 1470, 1450, 1390, 1305, 1255, 1095, 1050, 1030, 970, 820, 770, 735, 700 cm-1. 1H NMR: δH (CDCl3) 1.3 (6H, t, J=7 Hz, P-(OCH2CH3)2), 3.6 (4H, d, 2×CH2OCH2Ph),3.8-4.05 (1H, m, CH), 4.05 (2H, d, J=9 Hz, OCH2P), 4.0-4.3 (4H, m, P-(OCH2CH3)2), 4.55 (4H, s, 2×OCH2Ph), 7.38 (10H, s, 2×Ph). C22H31PO6 requires: C, 62.54; H, 7.42. Found: C, 62.75, H, 7.61. m/z: C22H31PO6 requires 422.1858; observed (M+) 422.1864.

Fuente