Reacción #633963

Ecuación de reacción

Chloroacetone

cesium carbonate

potassium iodide

N-(2,6-difluoropyridin-3-yl)formamide

→

title compound

N-(2,6-difluoropyridin-3-yl)-N-(2-oxopropyl)formamide

Disolventes

water

Ethyl acetate

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe organic layer was separated
2. 2
   LavadoThe resulting organic layer was washed with brine
3. 3
   Secadodried over anhydrous sodium sulfate
4. 4
   OtroThe drying agent was separated by filtration
5. 5
   Concentraciónthe organic layer was concentrated under reduced pressure
6. 6
   OtroThe residue was purified by silica gel column chromatography

Procedimiento

Chloroacetone (1.83 ml), cesium carbonate (7.99 g) and potassium iodide (254 mg) were added to a solution of N-(2,6-difluoropyridin-3-yl)formamide (2.42 g) in N,N-dimethylformamide (50 ml), and the reaction solution was stirred at room temperature for two hours. Ethyl acetate and water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate. The drying agent was separated by filtration, and then the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain the title compound (2.52 g). The property values of the compound are as follows.

Fuente