Reacción #633929

Ecuación de reacción

sodium bicarbonate

4-Chloroaniline

lithium tetrafluoroborate

oxetane

→

title compound

Rendimiento 67.9%

3-(4-chlorophenylamino)propan-1-ol

Rendimiento 67.9%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónfollowed by extraction with chloroform
2. 2
   ExtracciónThe resulting extract
3. 3
   Secadowas dried over magnesium sulfate
4. 4
   Concentraciónconcentrated under reduced pressure
5. 5
   OtroThe residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system)

Procedimiento

4-Chloroaniline (4.39 g) and lithium tetrafluoroborate (3.32 g) were added to a solution of oxetane (1.00 g) in acetonitrile (20 mL) at room temperature, and the reaction solution was stirred at room temperature for 52 hours. A saturated sodium bicarbonate solution was added to the reaction solution, followed by extraction with chloroform. The resulting extract was dried over magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system) to obtain 2.17 g of the title compound. The property values of the compound are as follows.

Fuente