Reacción #63362

ord-8912190ed3464e4091fb6280002f0b9a

Ecuación de reacción

CCCN1C(=O)C2(c3ccc([N+](=O)[O-])cc3)CC(c3ccc([N+](=O)[O-])cc3)(C2)C1=O
1,5-di-(4-nitrophenyl)-3-n-propyl-3-azabicyclo[3.1.1]heptane-2,4-dione
CCOCC.ClCCl
ether methylene chloride
→
CCCN1C(=O)C2(c3ccc(N)cc3)CC(c3ccc(N)cc3)(C2)C1=O
1,5-di-(4-aminophenyl)-3-n-propyl-3-azabicyclo[3.1.1]heptane-2,4-dione

Reactantes

CCCN1C(=O)C2(c3ccc([N+](=O)[O-])cc3)CC(c3ccc([N+](=O)[O-])cc3)(C2)C1=O
1,5-di-(4-nitrophenyl)-3-n-propyl-3-azabicyclo[3.1.1]heptane-2,4-dione
CCOCC.ClCCl
ether methylene chloride

Reactivos

[Pd]
palladium-on-carbon

Disolventes

CCOC(C)=O
ethyl acetate

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

In a manner analogous to that described in Example 12a, 0.4 g of 1,5-di-(4-nitrophenyl)-3-n-propyl-3-azabicyclo[3.1.1]heptane-2,4-dione are dissolved in 15 ml of ethyl acetate, hydrogenated in the presence of 80 mg of 5% palladium-on-carbon and worked up. Melting point 149°-150° (from ether/methylene chloride).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04764640uspto-grants-1988_08