Reacción #633025

ord-71ccba08d965415795ceddb301216d16

Ecuación de reacción

CCOC(=O)CN1C(=O)C(CO)(c2cc3c(cc2O)OCC3)c2c(Cl)cccc21
ethyl [4-chloro-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-3-(hydroxymethyl)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetate
CCCCCN1C(=O)C(CO)(c2cc3c(cc2O)OCO3)c2c(Cl)ccc(Cl)c21
4,7-dichloro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one
CCOC(=O)CN1C(=O)C2(COc3cc4c(cc32)CCO4)c2c(Cl)cccc21
title compound
Rendimiento 63.0%
CCOC(=O)CN1C(=O)C2(COc3cc4c(cc32)CCO4)c2c(Cl)cccc21
ethyl (4′-chloro-2′-oxo-5,6-dihydrospiro[benzo[1,2-b:5,4-b′]difuran-3,3′-indol]-1′(2′H)-yl)acetate
Rendimiento 63.0%

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Following the procedure as described in EXAMPLE 1.22, and making non-critical variations using ethyl [4-chloro-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-3-(hydroxymethyl)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetate to replace 4,7-dichloro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one, the title compound was obtained in 63% yield as a colorless solid: MS (ES+) m/z 400.8 (M+1).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07935721B2uspto-grants-2011_05