Reacción #63256

Ecuación de reacción

potassium iodide

2-propyl-3,4-dichlorophenol

7-bromoheptanoic acid

potassium carbonate

→

desired title product

7-(2-Propyl-3,4-dichlorophenoxy)heptanoic acid

Disolventes

methyl ethyl ketone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux overnight
2. 2
   Otroevaporated in vacuo
3. 3
   workup.ADDITIONEthyl acetate and water were added to the residue
4. 4
   Otrothe layers were separated
5. 5
   workup.ADDITIONFresh water was added to the organic layer
6. 6
   Otrothe layers were separated
7. 7
   LavadoThe organic layer was washed with a saturated sodium chloride solution
8. 8
   Filtraciónfiltered through sodium sulfate
9. 9
   Otroevaporated to dryness
10. 10
    Otroto give 4.68 g

Procedimiento

A solution of 3.09 g. of 2-propyl-3,4-dichlorophenol, 3.1 g. of 7-bromoheptanoic acid, 3.1 g. of potassium carbonate, and 2.0 g. of potassium iodide in 50 ml. of methyl ethyl ketone was heated at reflux overnight. The reaction mixture was cooled to room temperature and evaporated in vacuo. Ethyl acetate and water were added to the residue and the layers were separated. Fresh water was added to the organic layer, the pH was adjusted to 2.0 with acid, and the layers were separated. The organic layer was washed with a saturated sodium chloride solution, filtered through sodium sulfate, and evaporated to dryness to give 4.68 g. of the desired title product.

Fuente