Reacción #63250

Ecuación de reacción

4-(2-propyl-3- chloro-4-acetylphenoxy)butane nitrile

tetramethylguanidinium azide

ethyl acetate

dimethylformamide

→

desired title product

5-[4-(2-Propyl-3-chloro-4-acetylphenoxy)butyl]-tetrazole

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction was cooled
2. 2
   Otrothe layers were separated
3. 3
   workup.ADDITIONWater was added to the ethyl acetate layer
4. 4
   Otrothe layers were separated
5. 5
   SecadoThe ethyl acetate was dried
6. 6
   Otroevaporated to dryness
7. 7
   OtroThe residue was purified by chromatography

Procedimiento

A solution of 0.5 g. of 4-(2-propyl-3- chloro-4-acetylphenoxy)butane nitrile and 1.3 g. of tetramethylguanidinium azide in 3 ml. of dimethylformamide was heated overnight at 125° C. The reaction was cooled, ethyl acetate and water were added, and the layers were separated. Water was added to the ethyl acetate layer, the water layer was acidified, and the layers were separated. The ethyl acetate was dried and evaporated to dryness. The residue was purified by chromatography to give the desired title product. NMR.

Fuente