Reacción #63218

Ecuación de reacción

t-butyl [2-(4-chloro-3-methylpyridine-2-carboxamido)ethyl]carbamate

trifluoroacetic acid

hydrochloride

t-butyl [2-(4-chloro-3-methylpyridine-2-carboxamido)ethyl]carbamate

→

N-(2-aminoethyl)-4-chloro-3-methylpyridine-2-carboxamide hydrochloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas recrystallized from ethanol/ether

Procedimiento

12.5 g of t-butyl [2-(4-chloro-3-methylpyridine-2-carboxamido)ethyl]carbamate were reacted with trifluoroacetic acid in an analogous manner to that described in Example 2, paragraph 2. The residue was converted into the hydrochloride which was recrystallized from ethanol/ether, whereby there was obtained N-(2-aminoethyl)-4-chloro-3-methylpyridine-2-carboxamide hydrochloride as white crystals, m.p. 180°-181°.

Fuente