Reacción #632027

Ecuación de reacción

3-quinuclidinone

benzaldehyde

sodium hydroxide

→

(Z)-2-benzylidenequinuclidin-3-one

Rendimiento 91.2%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 1.5 h
2. 2
   TemperaturaAfter the solution was cooled
3. 3
   Otrothe yellow precipitates
4. 4
   Otrowere collected
5. 5
   Lavadowashed with ethanol
6. 6
   Otrodried

Procedimiento

A mixture of 3-quinuclidinone (20.9 g, 167 mmol), benzaldehyde (17.7 g, 167 mmol), and one pellet of sodium hydroxide in 75 mL of ethanol was refluxed for 1.5 h. After the solution was cooled, the yellow precipitates were collected, washed with ethanol, and dried to give (Z)-2-benzylidenequinuclidin-3-one (32.5 g, yield: 91.2%, mp 130-132° C.).

Fuente