Reacción #63199

Ecuación de reacción

3-(5,6,7,8-tetrahydroquinol-8-yl)propylamine

2-chloro-3-nitro-5-(pyrid-3-ylmethyl)pyridine hydrochloride

triethylamine

→

title compound

Rendimiento 86.5%

2-[3-(5,6,7,8-Tetrahydroquinol-8-yl)propylamino]-3-nitro-5-(pyrid-3-ylmethyl)pyridine

Rendimiento 86.5%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed in vacuo
2. 2
   workup.DISSOLUTIONthe residue was dissolved in chloroform
3. 3
   Otrochromatographed on silica in chloroform and later chloroform/methanol 4:1
4. 4
   workup.ADDITIONThe fractions containing the product
5. 5
   Concentraciónwere concentrated

Procedimiento

A mixture of 3-(5,6,7,8-tetrahydroquinol-8-yl)propylamine (4.5 g), 2-chloro-3-nitro-5-(pyrid-3-ylmethyl)pyridine hydrochloride (5 g) and triethylamine (10 ml) was refluxed in ethanol (200 ml) for 7.5 hours. The solvent was removed in vacuo, the residue was dissolved in chloroform and chromatographed on silica in chloroform and later chloroform/methanol 4:1. The fractions containing the product were concentrated to give the title compound as an oil (6.1 g).

Fuente