Reacción #631971

ord-43b48e2ce5cd45609b530a2602e1348d

Ecuación de reacción

C=CC(=O)OCCC(=O)O
2-Carboxyethyl acrylate
O=S(Cl)Cl
Thionyl chloride
→
C=CC(=O)OCCC(=O)Cl
desired product
C=CC(=O)OCCC(=O)Cl
3-chloro-3-oxopropyl acrylate

Reactantes

C=CC(=O)OCCC(=O)O
2-Carboxyethyl acrylate
O=S(Cl)Cl
Thionyl chloride

Reactivos

Ninguno

Disolventes

ClCCl
CH2Cl2

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Temperaturathe solution is cooled in an ice bath
  2. 2
    OtroThe solvent is removed under reduced pressure

Procedimiento

2-Carboxyethyl acrylate (1 eq.) is dissolved in CH2Cl2 and the solution is cooled in an ice bath. Thionyl chloride (1 eq.) is added dropwise and the mixture is allowed to warm to room temperature and stir for 4 hours. The solvent is removed under reduced pressure and the desired product is isolated by vacuum distillation.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07935131B2uspto-grants-2011_05