Reacción #631087

ord-2b493799415144a5a9877d7c4423cd41

Ecuación de reacción

CC(C)C(N)C(=O)OCc1cccc(C(=O)c2ccccc2)n1
(6-benzoyl-2-pyridyl)methyl 2-amino-3-methylbutanoate
C=C(Cl)CBr
2-chloro-2-propen-1-yl bromide
CC(Cl)=CCCl
3-chloro-2-buten-1-yl chloride
→
CC(Cl)=CCNC(C(=O)OCc1cccc(C(=O)c2ccccc2)n1)C(C)C
(6-benzoyl-2-pyridyl)methyl 2-[N-(3-chloro-2-butenyl)amino]-3-methylbutanoate
C=C(Cl)CNC(C(=O)OCc1cccc(C(=O)c2ccccc2)n1)C(C)C
(6-benzoyl-2-pyridyl)methyl 2-[N-(2-chloro-2-propenyl)amino]-3-methylbutanoate

Reactantes

CC(C)C(N)C(=O)OCc1cccc(C(=O)c2ccccc2)n1
(6-benzoyl-2-pyridyl)methyl 2-amino-3-methylbutanoate
C=C(Cl)CBr
2-chloro-2-propen-1-yl bromide
CC(Cl)=CCCl
3-chloro-2-buten-1-yl chloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Using the method of Example 2, (6-benzoyl-2-pyridyl)methyl 2-amino-3-methylbutanoate is reacted with each of 2-chloro-2-propen-1-yl bromide and 3-chloro-2-buten-1-yl chloride to yield (6-benzoyl-2-pyridyl)methyl 2-[N-(2-chloro-2-propenyl)amino]-3-methylbutanoate and (6-benzoyl-2-pyridyl)methyl 2-[N-(3-chloro-2-butenyl)amino]-3-methylbutanoate.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04447613uspto-grants-1984_05