Reacción #6306

Ecuación de reacción

2-(4-methylphenyl)benzoxazole

N-bromosuccinimide

benzoyl peroxide

→

2-(4-Bromomethylphenyl)benzoxazole

Disolventes

carbon tetrachloride

carbon tetrachloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 20 hours
2. 2
   Otrothe solid byproducts are removed by filtration
3. 3
   ConcentraciónThe filtrate is concentrated in vacuo
4. 4
   Otrothe product is purified by recrystallization from benzene

Procedimiento

A stirred solution of 20.9 g (0.1 mole) of 2-(4-methylphenyl)benzoxazole, 17.8 g (0.1 mole) of N-bromosuccinimide, and 0.4 g (0.2 mole %) of benzoyl peroxide in carbon tetrachloride is heated at reflux for 20 hours. After cooling to room temperature, the reaction is diluted by the addition of carbon tetrachloride, and the solid byproducts are removed by filtration. The filtrate is concentrated in vacuo, and the product is purified by recrystallization from benzene.

Fuente