Reacción #62979

Ecuación de reacción

nitric acid

4-benzyloxyphenol

→

nitrophenol

Rendimiento 37.0%

2-nitro-4-benzyloxyphenol

Rendimiento 37.0%

Disolventes

ethylacetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed in separatory funnel with sodium hydrogen carbonate in water (saturated solution)
2. 2
   OtroThe organic layer was separated
3. 3
   Otroevaporated under vacuum
4. 4
   Otrothe residual solid was crystallized from methanol (100 ml)

Procedimiento

Fumic nitric acid (d=1.52, 43.6 g, 0.70 mole) was dropwise added under stirring to 4-benzyloxyphenol (138.0 g, 0.69 mole) in ethylacetate (500 ml) at 0° C. The resulting solution was raised at room temperature and then washed in separatory funnel with sodium hydrogen carbonate in water (saturated solution). The organic layer was separated and evaporated under vacuum and the residual solid was crystallized from methanol (100 ml) to give nitrophenol (Yield of (a): 62.54 g, 36%) as yellow prisms. The product structure was confirmed by NMR and IR spectra.

Fuente