Reacción #62969

Ecuación de reacción

potassium

4-hydroxy-4'-nitrobiphenyl

6-iodo-1-hexanol

18-crown-6 ether

potassium

→

4-(6-Hydroxyhexyloxy)-4'-nitrobiphenyl

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONhas dissolved
2. 2
   Otroreacted
3. 3
   FiltraciónThe solution is filtered hot
4. 4
   OtroAfter solvent removal
5. 5
   Otrothe solid residue is recrystallized from ethanol
6. 6
   Otroto yield a purified product, m.p. 117°-119° C.

Procedimiento

To 500 ml of toluene in a one liter round bottom flask, fitted with a condenser and magnetic stirrer, are added 7.6 g (0.03M) of the potassium salt of 4-hydroxy-4'-nitrobiphenyl, 4.9 g (0.035M) of 6-iodo-1-hexanol, and 0.5 g of 18-crown-6 ether. The mixture is refluxed for about 20 hours until all of the potassium salt has dissolved and reacted as evidenced by the absence of the blue crystalline solid. The solution is filtered hot, and then cooled to room temperature. After solvent removal, the solid residue is recrystallized from ethanol to yield a purified product, m.p. 117°-119° C.

Fuente