Reacción #628751

Ecuación de reacción

4-Bromo-1-fluoro-2-nitrobenzene

potassium carbonate

2-propanethiol

→

desired compound

Rendimiento 96.6%

4-Bromo-1-(isopropylthio)-2-nitrobenzene

Rendimiento 96.6%

Disolventes

N,N-dimethylformamide

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was cooled to rt
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   LavadoThe extracts were washed with brine
4. 4
   Secadodried over sodium sulfate
5. 5
   Otroevaporated

Procedimiento

4-Bromo-1-fluoro-2-nitrobenzene (1.0 g, 4.5 mmol) [Aldrich] and potassium carbonate (1.6 g, 11 mmol) were stirred in N,N-dimethylformamide (10 mL), and 2-propanethiol (0.42 mL, 4.5 mmol) was added. The mixture was heated to 100° C. for 16 hours. The mixture was cooled to rt, diluted with water (100 mL), and extracted with ethyl acetate. The extracts were washed with brine, dried over sodium sulfate, and evaporated to give the desired compound (1.2 g, 96%). 1H NMR (300 MHz, CDCl3): δ 8.27 (s, 1H), 7.62 (d, 1H), 7.38 (d, 1H), 3.55 (m, 1H), 1.40 (d, 6H).

Fuente