Reacción #62874

Ecuación de reacción

4-chloro-5-ethoxycarbonylmethyl-2-(2-methylprop-2-yl)pyrimidine

2-iodo-propane

lithium bis(trimethylsilyl)amide

→

ethyl (RS)-2-[2-(2-methylprop-2-yl)-4-chloropyrimidin-5-yl]-3-methylbutyrate

Condiciones de reacción

Procedimiento

4-chloro-5-ethoxycarbonylmethyl-2-(2-methylprop-2-yl)pyrimidine was reacted with 2-iodo-propane in the presence of lithium bis(trimethylsilyl)amide according to the procedure illustrated in example 6, to give ethyl (RS)-2-[2-(2-methylprop-2-yl)-4-chloropyrimidin-5-yl]-3-methylbutyrate.

Fuente