Reacción #62805

Ecuación de reacción

(±)-3,4,5,8-tetrahydro-7-methyl-5-(3-nitrophenyl)-4-oxo-pyrido[2,3-d]-pyrimidine-6-carboxylic acid isopropyl ester

trimethyloxonium tetrafluoroborate

→

(±)-5,8-Dihydro-4-methoxy-7-methyl-5-(3-nitrophenyl)pyrido[2,3-d]pyrimidine-6-carboxylic acid isopropyl ester

Disolventes

1,2-dichloroethane

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe product is extracted twice with 50 ml saturated sodium hydrogen carbonate solution
2. 2
   Otrothe organic phase is separated
3. 3
   Secadodried over sodium sulfate
4. 4
   OtroTwice recrystallizing the residue from diisopropyl ether/isopropanol
5. 5
   Otroyields the product in the form of colorless crystals with a mp of 212°-213° C.

Procedimiento

Three and 0.7 g (10 mmol) (±)-3,4,5,8-tetrahydro-7-methyl-5-(3-nitrophenyl)-4-oxo-pyrido[2,3-d]-pyrimidine-6-carboxylic acid isopropyl ester and 3.0 g (20 mmol) trimethyloxonium-tetrafluoroborate are stirred in 150 ml 1,2-dichloroethane in nitrogen atmosphere and at room temperature for three hours. The product is extracted twice with 50 ml saturated sodium hydrogen carbonate solution, the organic phase is separated, dried over sodium sulfate and reduced under vacuum. Twice recrystallizing the residue from diisopropyl ether/isopropanol yields the product in the form of colorless crystals with a mp of 212°-213° C.

Fuente