Reacción #62785

Ecuación de reacción

Trichloroacetyl chloride

N-(3-chloro)allyl-N-methoxyethylamine

triethylamine

→

above-named product

Rendimiento 92.7%

N-(3-chloro)allyl-N-methoxyethyl trichloroacetamide

Rendimiento 92.7%

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction was kept at approximately 5° C. with an ice-water bath
2. 2
   workup.ADDITIONUpon completion of the addition
3. 3
   LavadoThe reaction mixture was then washed twice with saturated brine
4. 4
   Secadodried with sodium sulfate
5. 5
   OtroRotary evaporation

Procedimiento

N-(3-chloro)allyl-N-methoxyethylamine (2.25 g, 0.015 mol) and 1.52 g (0.015 mol) triethylamine were stirred in 70 ml dichloromethane. The reaction was kept at approximately 5° C. with an ice-water bath. Trichloroacetyl chloride (2.73 g, 0.015 mol) in 10 ml dichloromethane was added dropwise to the cooled solution. Upon completion of the addition, the mixture was stirred at room temperature for 6 hours. The reaction mixture was then washed twice with saturated brine and dried with sodium sulfate. Rotary evaporation yielded 4.1 g of the above-named product.

Fuente