Reacción #62685

Ecuación de reacción

Oxalic acid

Na2SO4

dihydropyran

4-(2-hydroxyethyl)phenol

NaOH

→

4-(2-tetrahydropyran-2-yloxyethyl)phenol

Disolventes

water

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with CH2Cl2 (2X)
2. 2
   workup.STIRRINGThe mixture was stirred vigorously for one hour
3. 3
   LavadoThe organic phase was washed with water (3×1 l)
4. 4
   Otroevaporated

Procedimiento

Oxalic acid (64 g, 0.5 mol), Na2SO4 (400 g) and distilled dihydropyran (600 mL) are added to a solution of 4-(2-hydroxyethyl)phenol (600 g, 4.3 mol) in acetone (3 l) and the mixture stirred for 3 hours. The resulting solution is added to water (4 l) containing 35% NaOH solution (500 mL), and washed with CH2Cl2 (2X). The mixture was stirred vigorously for one hour. The organic phase was washed with water (3×1 l) and evaporated to yield 4-(2-tetrahydropyran-2-yloxyethyl)phenol (9).

Fuente