Reacción #62548

Ecuación de reacción

Methyl chloroacetate

N-methylpiperazine

→

2-(4-methyl-1-piperazinyl)acetic acid, methyl ester

Rendimiento 95.0%

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe reaction mixture was filtered
2. 2
   Otrothe solvent was removed under vacuum
3. 3
   workup.DISSOLUTIONThe resulting oil was dissolved in methylene chloride-methanol (9:1)
4. 4
   Otropurified by flash chromatography (silica)

Procedimiento

Methyl chloroacetate (8.8 ml., 0.10 mole) was added to a solution of N-methylpiperazine (24.4. ml., 0.22 mole) in ethyl acetate (140 ml.) and the mixture was stirred for 17 hours. The reaction mixture was filtered and the solvent was removed under vacuum. The resulting oil was dissolved in methylene chloride-methanol (9:1) and purified by flash chromatography (silica) to give 2-(4-methyl-1-piperazinyl)acetic acid, methyl ester as an oil (16.3 g, 95%).

Fuente