Reacción #62507

Ecuación de reacción

6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline

pentafluorophenyl-tetramethyluronium hexafluorophosphate

diisopropylethylamine

3-tert.-butyloxycarbonylamino-pyrrolidine

trifluoroacetic acid

→

6-chloro-4-[(1R/S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-[(3R/S)-3-amino-pyrrolidin-1-yl-carbonyl]-quinazoline

Disolventes

DMSO

Condiciones de reacción

Procedimiento

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and 3-tert.-butyloxycarbonylamino-pyrrolidine in DMSO at ambient temperature and subsequent treatment with trifluoroacetic acid.

Fuente