Reacción #62463

Ecuación de reacción

6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline

pentafluorophenyl-tetramethyluronium hexafluorophosphate

diisopropylethylamine

(S)-2-(phenylaminomethyl)-pyrrolidine

→

6-chloro-4-[(1R/S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-[(2S)-2-(phenylaminomethyl)-pyrrolidin-1-yl-carbonyl]-quinazoline

Disolventes

DMSO

Condiciones de reacción

Procedimiento

Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and (S)-2-(phenylaminomethyl)-pyrrolidine in DMSO at ambient temperature.

Fuente