Reacción #62406

Ecuación de reacción

1-(5-bromo-6-fluoro-indazol-1-yl)ethanone

sodium hydroxide

→

title compound

Rendimiento 88.7%

5-Bromo-6-fluoro-1H-indazole

Rendimiento 88.7%

Disolventes

hydrochloric acid

ethanol

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe organic layer was successively washed with water and saturated brine
2. 2
   Secadodried over anhydrous magnesium sulfate
3. 3
   Otrothe solvent was evaporated
4. 4
   OtroThe residue was purified
5. 5
   Otroseparated by silica gel column chromatography (ethyl acetate:n-hexane=1:3)

Procedimiento

To a solution of 22.5 g of 1-(5-bromo-6-fluoro-indazol-1-yl)ethanone in 250 mL of ethanol was added 20.0 mL of 5N sodium hydroxide aqueous solution at room temperature, and stirred at this temperature for 5 minutes. After neutralizing in 5N hydrochloric acid aqueous solution, the solution was diluted with ethyl acetate. The organic layer was successively washed with water and saturated brine, dried over anhydrous magnesium sulfate, and then the solvent was evaporated. The residue was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:3), to afford 16.7 g of the title compound as pale brown crystals.

Fuente