Reacción #623841

Ecuación de reacción

PhCH2MgCl

1,2,4-trimethyl-pyridinium iodide

→

title compound

2-Benzyl-1,4,6-trimethyl-1,2-dihydro-pyridine

Disolventes

Et2O

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturachilled in an ice bath
2. 2
   Otrothe precipitate formed
3. 3
   Otrois separated by filtration
4. 4
   LavadoThe precipitate is washed with methanol
5. 5
   Otrodried

Procedimiento

PhCH2MgCl (1 M in Et2O, 180 mL) is added dropwise to a solution of 1,2,4-trimethyl-pyridinium iodide (24.3 g) in Et2O(90 mL) chilled in an ice bath. After stirring in the ice bath for 2 h, the solution is poured into a mixture of 72% aqueous HClO4 (40 mL) and crushed ice (ca. 900 mL). The resulting mixture is stirred for 1 h and the precipitate formed is separated by filtration. The precipitate is washed with methanol and dried to afford the HClO4 salt of the title compound.

Fuente