Reacción #6236

Ecuación de reacción

Hydrazine monohydrate

4-(3-phthalimidopropyloxy)pyridine

ethyl acetate

→

desired compound

Rendimiento 99.5%

4-(3-aminopropyloxy)pyridine

Rendimiento 99.5%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtracióninsoluble materials were filtered off
2. 2
   workup.DISTILLATIONThe volatile component in the filtrate was distilled off
3. 3
   workup.ADDITIONchloroform was added to the residue
4. 4
   LavadoThe mixture was washed with brine
5. 5
   Secadodried over potassium carbonate
6. 6
   workup.DISTILLATIONThe solvent was distilled off

Procedimiento

Hydrazine monohydrate [2.99 ml (61.6 mmol)] was added to a suspension of 5.80 g (20.5 mol) of 4-(3-phthalimidopropyloxy)pyridine in 50 ml of ethanol, and the mixture was stirred at room temperature for 3 hours. 100 ml of ethyl acetate was added and insoluble materials were filtered off. The volatile component in the filtrate was distilled off and then chloroform was added to the residue. The mixture was washed with brine and dried over potassium carbonate. The solvent was distilled off to obtain 2.99 g of the desired compound (yield: 99.5%, pale yellow oil).

Fuente