Reacción #62353

Ecuación de reacción

1-acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile

hydrochloric acid

→

title compound

Rendimiento 100.2%

1H-Thieno[2,3-c]pyrazole-5-carbonitrile

Rendimiento 100.2%

Disolventes

ethanol

sodium hydroxide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   Lavadothe organic layer was washed with saturated brine
4. 4
   Secadodried over anhydrous magnesium sulfate
5. 5
   Otrothe solvent was evaporated

Procedimiento

To a suspension of 215 mg of 1-acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile in 8 mL of ethanol, 1 mL of 5N sodium hydroxide aqueous solution was added at room temperature, and stirred at this temperature for 10 minutes. Then the solution was neutralized with 5N hydrochloric acid, extracted with ethyl acetate, and the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 168 mg of the title compound as colorless crystals.

Fuente