Reacción #62351

Ecuación de reacción

5-chloro-4-hydroxymethylthiophene-2-carbonitrile

Dess-Martin reagent

→

crude product

Rendimiento 151.8%

5-Chloro-4-formylthiophene-2-carbonitrile

Rendimiento 151.8%

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashing successively with aqueous sodium hydrogen carbonate and saturated brine
2. 2
   Secadodrying over anhydrous magnesium sulfate
3. 3
   Otrothe solvent was evaporated

Procedimiento

To a solution of 3.0 g of 5-chloro-4-hydroxymethylthiophene-2-carbonitrile in 34 mL of dichloromethane was added 8.06 g of Dess-Martin reagent at room temperature, and stirred at this temperature for a day. After diluting with dichloromethane, washing successively with aqueous sodium hydrogen carbonate and saturated brine, and drying over anhydrous magnesium sulfate, the solvent was evaporated, to afford 4.5 g of a crude product of the title compound as colorless crystals.

Fuente