Reacción #62345

Ecuación de reacción

3-iodo-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile

diisopropylethylamine

trityl chloride

→

title compound

Rendimiento 47.3%

3-Iodo-1-trityl-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile

Rendimiento 47.3%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solution was evaporated
2. 2
   workup.ADDITIONdiluted with ethyl acetate
3. 3
   Lavadowashed successively with saturated ammonium chloride and saturated brine
4. 4
   Secadodried over anhydrous magnesium sulfate
5. 5
   OtroThe solvent was evaporated
6. 6
   Otrothe crude product was purified
7. 7
   Otroseparated by silica gel column chromatography (ethyl acetate:n-hexane=1:10)

Procedimiento

To a solution of 5.8 g of 3-iodo-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile in 70 mL of dichloromethane were added 13.1 mL of diisopropylethylamine, 2.4 g of tetra-n-butylammonium iodide and 12.0 g of trityl chloride at room temperature, and stirred at this temperature for a day. The solution was evaporated, diluted with ethyl acetate, washed successively with saturated ammonium chloride and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:10), to afford 5.2 g of the title compound as colorless crystals.

Fuente